Malignant bile duct neoplasms most frequently harbor alterations in TP53, KRAS, IDH1, ARID1A, and CDKN2A [2].

Most Commonly Altered Genes in Malignant Bile Duct Neoplasm

TP53 Mutation, KRAS Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and KRAS Exon 2 Mutation are the most common alterations in malignant bile duct neoplasm [2].

Top Alterations in Malignant Bile Duct Neoplasm

Disease Details

Malignant Hepatobiliary Neoplasm
Bile Duct Sarcoma and Bile Duct Carcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.