Malignant colorectal neoplasms most frequently harbor alterations in TP53, APC, KRAS, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Malignant Colorectal Neoplasm

TP53 Mutation, APC Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and KRAS Mutation are the most common alterations in malignant colorectal neoplasm [2].

Top Alterations in Malignant Colorectal Neoplasm

Significant Genes in Malignant Colorectal Neoplasm


Disease Details

Malignant Intestinal Neoplasm
Colorectal Carcinoma, Colorectal Sarcoma, Malignant Rectosigmoid Neoplasm, Malignant Rectal Neoplasm, Malignant Colon Neoplasm, and Rectosigmoid Junction Cancer


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.