Overview

Malignant colorectal neoplasms most frequently harbor alterations in TP53, APC, KRAS, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Malignant Colorectal Neoplasm

APC Mutation, TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, and KRAS Mutation are the most common alterations in malignant colorectal neoplasm [2].

Top Alterations in Malignant Colorectal Neoplasm

Significant Genes in Malignant Colorectal Neoplasm

ERBB2 +

KRAS +

Disease Details

Parent(s)
Malignant Intestinal Neoplasm
Children
Colorectal Carcinoma, Colorectal Sarcoma, Malignant Rectal Neoplasm, Malignant Rectosigmoid Neoplasm, and Malignant Colon Neoplasm

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.