Malignant esophageal neoplasms most frequently harbor alterations in TP53, CDKN2A, ERBB2, KRAS, and ARID1A [2].

Most Commonly Altered Genes in Malignant Esophageal Neoplasm

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, TP53 Exon 8 Mutation, and TP53 Exon 5 Mutation are the most common alterations in malignant esophageal neoplasm [2].

Top Alterations in Malignant Esophageal Neoplasm

Significant Genes in Malignant Esophageal Neoplasm


Disease Details

Malignant Esophagogastric Neoplasm
Esophageal Granular Cell Tumor, Esophageal Melanoma, Esophageal Carcinoma, Esophageal Lymphoma, and Esophageal Sarcoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.