Overview

NCI Definition: A primary or metastatic malignant neoplasm involving the larynx. The majority are carcinomas. [1]

Malignant laryngeal neoplasms most frequently harbor alterations in TP53, CDKN2A, PIK3CA, KMT2D, and CCND1 [2].

Most Commonly Altered Genes in Malignant Laryngeal Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KMT2D Mutation, and PIK3CA Mutation are the most common alterations in malignant laryngeal neoplasm [2].

Top Alterations in Malignant Laryngeal Neoplasm

Significant Genes in Malignant Laryngeal Neoplasm

ABL1 +

BRAF +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB4 +

FGFR1 +

FGFR2 +

FLT1 +

FLT4 +

FRK +

KDR +

KIT +

MAPK11 +

PDGFRA +

PDGFRB +

RAF1 +

RET +

TEK +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

Disease Details

Synonyms
Malignant Larynx Tumor, Malignant Laryngeal Tumor, Malignant Tumor of Larynx, Malignant Neoplasm of the Larynx, Malignant Tumor of the Larynx, Malignant Neoplasm of Larynx, Malignant Larynx Neoplasm
Parent(s)
Malignant Head and Neck Neoplasm
Children
Malignant Subglottic Neoplasm, Malignant Supraglottis Neoplasm, Malignant Supraglottic Neoplasm, Malignant Glottis Neoplasm, Laryngeal Sarcoma, and Laryngeal Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.