Overview

NCI Definition: A primary or metastatic malignant neoplasm affecting the thyroid gland. [1]

Malignant thyroid gland neoplasms most frequently harbor alterations in BRAF, RET, TP53, NRAS, and CDKN2A [2].

Most Commonly Altered Genes in Malignant Thyroid Gland Neoplasm

BRAF Mutation, BRAF Exon 15 Mutation, BRAF Codon 600 Missense, BRAF V600E, and NRAS Mutation are the most common alterations in malignant thyroid gland neoplasm [2].

Top Alterations in Malignant Thyroid Gland Neoplasm

Significant Genes in Malignant Thyroid Gland Neoplasm

HRAS +

Disease Details

Synonyms
Malignant Neoplasm of the Thyroid, Malignant Tumor of the Thyroid Gland, Malignant Tumor of Thyroid, Malignant Tumor of the Thyroid, Malignant Neoplasm of the Thyroid Gland, Malignant Neoplasm of Thyroid, Malignant Thyroid Neoplasm, Malignant Tumor of Thyroid Gland, Malignant Thyroid Gland Tumor, Malignant Neoplasm of Thyroid Gland, Malignant Thyroid Tumor
Parent(s)
Thyroid Gland Neoplasm
Children
Thyroid Gland Lymphoma, Thyroid Gland Carcinoma, and Thyroid Gland Sarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.