Overview

NCI Definition: A primary or metastatic malignant neoplasm affecting the thyroid gland. [1]

Malignant thyroid gland neoplasms most frequently harbor alterations in BRAF, NRAS, TP53, RET, and HRAS [2].

Most Commonly Altered Genes in Malignant Thyroid Gland Neoplasm

BRAF Mutation, BRAF Exon 15 Mutation, BRAF V600E, BRAF Codon 600 Missense, and NRAS Mutation are the most common alterations in malignant thyroid gland neoplasm [2].

Top Alterations in Malignant Thyroid Gland Neoplasm

Significant Genes in Malignant Thyroid Gland Neoplasm

ERBB2 +

HRAS +

Disease Details

Synonyms
Malignant Tumor of the Thyroid, Malignant Thyroid Gland Tumor, Malignant Thyroid Tumor, Malignant Neoplasm of the Thyroid Gland, Malignant Neoplasm of the Thyroid, Malignant Tumor of Thyroid, Malignant Neoplasm of Thyroid, Malignant Tumor of the Thyroid Gland, Malignant Thyroid Neoplasm, Malignant Tumor of Thyroid Gland, Malignant Neoplasm of Thyroid Gland
Parent(s)
Thyroid Gland Neoplasm
Children
Thyroid Gland Sarcoma, Thyroid Gland Lymphoma, and Thyroid Gland Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.