Melanoma of unknown primarys most frequently harbor alterations in BRAF, CDKN2A, TP53, ROS1, and NF1 [2].

Most Commonly Altered Genes in Melanoma of Unknown Primary

BRAF Mutation, BRAF Exon 15 Mutation, BRAF Codon 600 Missense, ROS1 Mutation, and BRAF V600E are the most common alterations in melanoma of unknown primary [2].

Top Alterations in Melanoma of Unknown Primary

Significant Genes in Melanoma of Unknown Primary


Disease Details

Melanoma of Unknown Primary Origin, Malignant melanoma of unknown origin, Malignant melanoma of unknown primary, Unknown primary melanoma
OncoTree Name
Melanoma of Unknown Primary
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.