Overview

Nasal cavity and paranasal sinus carcinomas most frequently harbor alterations in TP53, CDKN2A, KMT2D, PTEN, and PIK3CA [2].

Most Commonly Altered Genes in Nasal Cavity and Paranasal Sinus Carcinoma

TP53 Mutation, KMT2D Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, and TP53 c.1-c.137 Missense are the most common alterations in nasal cavity and paranasal sinus carcinoma [2].

Top Alterations in Nasal Cavity and Paranasal Sinus Carcinoma

Significant Genes in Nasal Cavity and Paranasal Sinus Carcinoma

ABL1 +

BRAF +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB4 +

FGFR1 +

FGFR2 +

FLT1 +

FLT4 +

FRK +

KDR +

KIT +

MAPK11 +

PDGFRA +

PDGFRB +

RAF1 +

RET +

TEK +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

Disease Details

Parent(s)
Paranasal Sinus and Nasal Cavity Cancer
Children
Nasal Cavity and Paranasal Sinus Neuroendocrine Carcinoma, Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma, Sinonasal Adenocarcinoma, Nasal Cavity Carcinoma, and Sinonasal Undifferentiated Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.