Overview

Nasal cavity and paranasal sinus carcinomas most frequently harbor alterations in TP53, CDKN2A, PTEN, PIK3CA, and KMT2D [2].

Most Commonly Altered Genes in Nasal Cavity and Paranasal Sinus Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Nonsense, TP53 Missense, and PIK3CA Mutation are the most common alterations in nasal cavity and paranasal sinus carcinoma [2].

Top Alterations in Nasal Cavity and Paranasal Sinus Carcinoma

Significant Genes in Nasal Cavity and Paranasal Sinus Carcinoma

ABL1 +

BRAF +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB4 +

FGFR1 +

FGFR2 +

FLT1 +

FLT4 +

FRK +

KDR +

KIT +

MAPK11 +

PDGFRA +

PDGFRB +

RAF1 +

RET +

TEK +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

Disease Details

Parent(s)
Paranasal Sinus and Nasal Cavity Cancer
Children
Nasal Cavity Carcinoma, Nasal Cavity and Paranasal Sinus Neuroendocrine Carcinoma, Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma, Sinonasal Undifferentiated Carcinoma, and Sinonasal Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.