Overview

Oropharyngeal carcinomas most frequently harbor alterations in TP53, PIK3CA, KMT2D, CDKN2A, and NOTCH1 [2].

Most Commonly Altered Genes in Oropharyngeal Carcinoma

TP53 Mutation, PIK3CA Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and KMT2D Mutation are the most common alterations in oropharyngeal carcinoma [2].

Top Alterations in Oropharyngeal Carcinoma

Significant Genes in Oropharyngeal Carcinoma

ABL1 +

BRAF +

DDR2 +

EGFR +

EPHA2 +

ERBB2 +

ERBB4 +

FGFR1 +

FGFR2 +

FLT1 +

FLT4 +

FRK +

KDR +

KIT +

MAPK11 +

PDGFRA +

PDGFRB +

RAF1 +

RET +

TEK +

TRNAK2 +

VEGFA +

VEGFB +

VEGFC +

Disease Details

Parent(s)
Malignant Oropharyngeal Neoplasm
Children
Oropharyngeal Squamous Cell Carcinoma and Tonsillar Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.