Associated Genetic Biomarkers

Overview

NCI Definition: A highly aggressive malignant neoplasm arising from the ovary. Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements. [1]

Ovarian carcinosarcomas most frequently harbor alterations in TP53, KRAS, CCNE1, PIK3CA, and RB1 [2].

Most Commonly Altered Genes in Ovarian Carcinosarcoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 5 Mutation, and TP53fs are the most common alterations in ovarian carcinosarcoma [2].

Top Alterations in Ovarian Carcinosarcoma

Significant Genes in Ovarian Carcinosarcoma

ABCB1 +

BRCA1 +

BRCA2 +

EGFR +

Disease Details

Synonyms
Malignant Mixed Mesodermal Mullerian Tumor of the Ovary, Carcinosarcoma of the Ovary, Malignant Mixed Mesodermal Mullerian Neoplasm of the Ovary, Ovarian Malignant Mixed Mullerian Neoplasm, Ovarian Malignant Mixed Mesodermal (Mullerian) Tumor, Ovarian MMMT, Ovarian Malignant Mixed Mesodermal Mullerian Neoplasm, Malignant Mixed Mesodermal Mullerian Neoplasm of Ovary, Ovary carcinosarcoma, Carcinosarcoma of Ovary, Malignant Mixed Mesodermal Mullerian Tumor of Ovary, Ovarian Malignant Mixed Mullerian Tumor, Ovarian Malignant Mixed Mesodermal Mullerian Tumor, Ovarian Malignant Mesodermal (Mullerian) Mixed Tumor
Parent(s)
Malignant Ovarian Endometrioid Tumor
OncoTree Name
Ovarian Carcinosarcoma/Malignant Mixed Mesodermal Tumor
OncoTree Code
OCS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.