Diseases /
Ovarian Carcinosarcoma
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Associated Genetic Biomarkers
Overview
NCI Definition: A highly aggressive malignant neoplasm arising from the ovary. Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements. [1]
Ovarian carcinosarcomas most frequently harbor alterations in TP53, KRAS, CCNE1, PIK3CA, and RB1 [2].
TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, TP53 Exon 5 Mutation, and TP53fs are the most common alterations in ovarian carcinosarcoma [2].
Clinical Trials
Significant Genes in Ovarian Carcinosarcoma
Disease Details
References
1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].
2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.