Overview

NCI Definition: A carcinoma that arises from the pancreas showing both ductal and squamous differentiation. The squamous component should represent at least 30% of the malignant cellular infiltrate. The prognosis is usually worse than that of ductal adenocarcinoma. [1]

Pancreatic adenosquamous carcinomas most frequently harbor alterations in KRAS, TP53, CDKN2A, SMAD4, and CDKN2B [2].

Most Commonly Altered Genes in Pancreatic Adenosquamous Carcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, TP53 Mutation, and KRAS G12D are the most common alterations in pancreatic adenosquamous carcinoma [2].

Top Alterations in Pancreatic Adenosquamous Carcinoma

Disease Details

Synonyms
Adenosquamous Carcinoma of Pancreas, Pancreatic Adenoacanthoma, Pancreatic Mixed Squamous and Adenocarcinoma, Pancreas adenosquamous carcinoma, Adenosquamous Carcinoma of the Pancreas, Pancreatic Mucoepidermoid Carcinoma
Parent(s)
Adenosquamous Carcinoma
OncoTree Name
Adenosquamous Carcinoma of the Pancreas
OncoTree Code
PAASC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.