Overview

Peripheral T-cell lymphomas most frequently harbor alterations in TET2, RHOA, TP53, DNMT3A, and CIITA [2].

Most Commonly Altered Genes in Peripheral T-Cell Lymphoma

TET2 Mutation, TP53 Mutation, RHOA G17V, TET2 Nonsense, and TET2 c.5533-c.6005 Missense are the most common alterations in peripheral T-cell lymphoma [2].

Top Alterations in Peripheral T-Cell Lymphoma

Significant Genes in Peripheral T-Cell Lymphoma

ABL1 +

AFF1 +

ASXL1 +

BCL2 +

BCR +

DEK +

ELL +

FLT3 +

HRAS +

JAK2 +

KMT2A +

KRAS +

MECOM +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MYC +

NRAS +

NUP214 +

PBX1 +

RPN1 +

RUNX1 +

TCF3 +

TP53 +

Disease Details

Parent(s)
Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma
OncoTree Name
Peripheral T-Cell Lymphoma
OncoTree Code
PTCL

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.