Primary brain neoplasms most frequently harbor alterations in TP53, H3F3A, BRAF, PIK3CA, and NOTCH1 [2].

Most Commonly Altered Genes in Primary Brain Neoplasm

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, H3F3A K28M, and BRAF Mutation are the most common alterations in primary brain neoplasm [2].

Top Alterations in Primary Brain Neoplasm

Significant Genes in Primary Brain Neoplasm

IDH1 +

IDH2 +

Disease Details

Primary Brain Tumor
Brain Neoplasm
Brain Astrocytoma, Primary Brain Stem Neoplasm, and Malignant Primary Brain Neoplasm
OncoTree Name
Primary Brain Tumor
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.