Overview

NCI Definition: An adenocarcinoma arising from the rectum. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, rectal adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma. [1]

Significant Genes in Rectal Adenocarcinoma

PIK3CA +

UGT1A1 +

Disease Details

Synonyms
Rectum adenocarcinoma (CRC), Adenocarcinoma of Rectum, Adenocarcinoma - rectum, Adenocarcinoma of the Rectum
Parent(s)
Rectal Carcinoma
Children
Rectal Mucinous Adenocarcinoma and Rectal Signet Ring Cell Adenocarcinoma
OncoTree Name
Rectal Adenocarcinoma
OncoTree Code
READ

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.