Overview

NCI Definition: A malignant epithelial neoplasm that arises from the rectum and invades through the muscularis mucosa into the submucosa. The vast majority are adenocarcinomas. [1]

Rectal carcinomas most frequently harbor alterations in APC, TP53, KRAS, SMAD4, and FBXW7 [2].

Most Commonly Altered Genes in Rectal Carcinoma

APC Mutation, TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and KRAS Mutation are the most common alterations in rectal carcinoma [2].

Top Alterations in Rectal Carcinoma

Significant Genes in Rectal Carcinoma

BRAF +

KRAS +

NRAS +

Disease Details

Synonyms
Cancer of Rectum, Carcinoma of Rectum, Rectal Cancer, Cancer of the Rectum, Carcinoma of the Rectum
Parent(s)
Malignant Rectal Neoplasm
Children
Rectal Adenocarcinoma, Rectal Sarcomatoid Carcinoma, Rectal Squamous Cell Carcinoma, and Stage 0 Rectal Cancer

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.