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Refractory anemia with ring sideroblasts

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Associated Genetic Biomarkers

Overview

NCI Definition: A myelodysplastic syndrome characterized by an anemia in which 15% or more of the erythroid precursors are ring sideroblasts. The ring sideroblast is an erythroid precursor in which one third or more of the nucleus is encircled by granules which are positive for iron stain. (WHO, 2001) [1]

Clinical Trials

View Clinical Trials for Refractory anemia with ring sideroblasts

Significant Genes in Refractory anemia with ring sideroblasts

MECOM +

MLF1 +

NPM1 +

RPN1 +

Disease Details

Synonyms
Pure Sideroblastic Anemia, MDS with Ring Sideroblasts, MDS-RS, Refractory Anemia with Ringed Sideroblasts, Refractory Anemia with Ring Sideroblasts, Myelodysplastic Syndrome with Ring Sideroblasts, RARS
Parent(s)
Myelodysplastic Syndromes
Children
Refractory Cytopenia with Multilineage Dysplasia and Ring Sideroblasts and Myelodysplastic Syndrome with Ring Sideroblasts and Single Lineage Dysplasia
OncoTree Name
MDS with Ring Sideroblasts
OncoTree Code
MDSRS

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.