Overview

NCI Definition: A transitional cell carcinoma that arises from the renal pelvis and ureter. [1]

Renal pelvis and ureter urothelial carcinomas most frequently harbor alterations in TP53, KMT2D, FGFR3, KDM6A, and ARID1A [2].

Most Commonly Altered Genes in Renal Pelvis and Ureter Urothelial Carcinoma

TP53 Mutation, FGFR3 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and KMT2D Mutation are the most common alterations in renal pelvis and ureter urothelial carcinoma [2].

Top Alterations in Renal Pelvis and Ureter Urothelial Carcinoma

Disease Details

Synonyms
Urothelial Carcinoma of the Renal Pelvis and Ureter, Renal Pelvis and Ureter Transitional Cell Cancer, Urothelial Carcinoma of the Upper Urinary Tract, Transitional Cell Cancer of the Renal Pelvis and Ureter, Renal Pelvis and Ureter Transitional Cell Carcinoma, Transitional Cell Cancer of Renal Pelvis and Ureter, TCC of the Renal Pelvis and Ureter, Renal Pelvis and Ureter Urothelial Cancer, Upper Urinary Tract Urothelial Carcinoma, Transitional Cell Carcinoma of Renal Pelvis and Ureter, TCC of Renal Pelvis and Ureter, Renal Pelvis and Ureter TCC, Upper Tract Urothelial Cancer
Parent(s)
Urothelial Carcinoma
Children
Renal Pelvis Urothelial Carcinoma, Ureter Urothelial Carcinoma, and Infiltrating Renal Pelvis and Ureter Urothelial Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.