Associated Genetic Biomarkers

Overview

NCI Definition: A usually aggressive malignant neoplasm of the soft tissue or bone. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma. [1]

Significant Genes in Sarcoma

ABL2 +

ACVR1B +

APC +

ASXL1 +

ATM +

ATR +

BLM +

BRCA1 +

BRCA2 +

CDK12 +

CDKN1A +

CDKN1B +

CDKN2A +

CHD4 +

CYLD +

DICER1 +

DNMT3A +

ERBB2 +

ERBB3 +

EWSR1 +

EZH2 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLT3 +

FUS +

GATA3 +

HGF +

IDH1 +

KDM6A +

KDR +

KEAP1 +

KIT +

KMT2D +

KRAS +

MAGI2 +

MAP3K1 +

MED12 +

MET +

MSH2 +

MSH6 +

MYC +

NF1 +

NF2 +

NOTCH1 +

NOTCH2 +

NRAS +

NSD1 +

PIK3C2B +

PIK3CA +

PIK3CB +

PIK3R1 +

PTCH1 +

PTPN11 +

RB1 +

RICTOR +

RUNX1 +

SETD2 +

SMARCA4 +

SOX9 +

STAG2 +

TAF1 +

TAF15 +

TBX3 +

TET2 +

TP53 +

XPO1 +

Disease Details

Synonyms
Mesenchymal Tumor, Malignant, Unknown primary, sarcoma, SARCOMA, MALIGNANT, Sarcoma of Soft Tissue and Bone, Unknown primary sarcoma, Sarcoma of the Soft Tissue and Bone
Parent(s)
Malignant Solid Tumor
Children
Head and Neck Sarcoma, Spindle Cell Sarcoma, Liposarcoma, Mast Cell Sarcoma, Soft Tissue Sarcoma, Sarcomatosis, Small Cell Sarcoma, Ewing Sarcoma, Leiomyosarcoma, Radiation-Related Sarcoma, Osteosarcoma, Malignant Peripheral Nerve Sheath Tumor, Fibrosarcoma, Angiosarcoma, Sarcoma, NOS, and Bone Sarcoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.