Overview

Gene Location [1]
13q12.2
Pathway
Receptor tyrosine kinase/growth factor signaling
Variant Type
Fusion
Gene
FLT3

FLT3 Fusion is present in 0.12% of AACR GENIE cases, with acute myeloid leukemia, colon adenocarcinoma, myeloid neoplasm, invasive breast carcinoma, and myelodysplastic syndromes having the greatest prevalence [4].

Top Disease Cases with FLT3 Fusion

Significance of FLT3 Fusion in Diseases

Acute Lymphoblastic Leukemia +

B-Cell Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Mixed Phenotype Acute Leukemia +

Myelodysplastic Syndromes +

Malignant Solid Tumor +

Multiple Myeloma +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Lymphoma +

Colorectal Carcinoma +

Cancer +

Bladder Carcinoma +

Ovarian Carcinoma +

Breast Carcinoma +

Sarcoma +

Non-Small Cell Lung Carcinoma +

Anaplastic Astrocytoma +

B-Cell Lymphoblastic Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Glioblastoma +

Head And Neck Carcinoma +

Lymphoblastic Lymphoma +

Melanoma +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Pancreatic Carcinoma +

Secondary Acute Myeloid Leukemia +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.