Overview

NCI Definition: A benign, usually encapsulated slow growing tumor composed of Schwann cells. It affects peripheral and cranial nerves. It recurs infrequently and only rare cases associated with malignant transformation have been reported. [1]

Schwannomas most frequently harbor alterations in NF2, ARID1A, SMARCB1, FANCD2, and SDHC [2].

Most Commonly Altered Genes in Schwannoma

NF2fs, NF2 Mutation, NF2 Nonsense, ARID1A Mutation, and ARID1A Missense are the most common alterations in schwannoma [2].

Top Alterations in Schwannoma

Significant Genes in Schwannoma

ARAF +

BRAF +

CRKL +

HRAS +

IDH1 +

IDH2 +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

NF1 +

NF2 +

NRAS +

RAF1 +

SRC +

Disease Details

Synonyms
Benign Neurilemmoma, SCHWANNOMA, BENIGN, Benign Schwannoma, Neurinoma, Schwannoma (WHO Grade I), Neurilemmoma, Soft tissue schwannoma
Parent(s)
Nerve Sheath Neoplasm
Children
Melanotic Schwannoma, Acoustic Schwannoma, Schwannomatosis, Microcystic/Reticular Schwannoma, Cellular Schwannoma, Sympathetic Schwannoma, Plexiform Schwannoma, Trigeminal Schwannoma, and Peripheral Nerve Schwannoma
OncoTree Name
Schwannoma
OncoTree Code
SCHW

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.