Overview

NCI Definition: A benign, usually encapsulated slow growing tumor composed of Schwann cells. It affects peripheral and cranial nerves. It recurs infrequently and only rare cases associated with malignant transformation have been reported. [1]

Schwannomas most frequently harbor alterations in NF2, SMARCB1, FLT4, FAT1, and ARID1A [2].

Most Commonly Altered Genes in Schwannoma

NF2 Mutation, NF2 Frameshift, NF2 Nonsense, FLT4 Mutation, and FLT4 Missense are the most common alterations in schwannoma [2].

Top Alterations in Schwannoma

Significant Genes in Schwannoma

ARAF +

BRAF +

CRKL +

HRAS +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

NF1 +

NF2 +

NRAS +

RAF1 +

SRC +

Disease Details

Synonyms
Benign Neurilemmoma, Benign Schwannoma, SCHWANNOMA, BENIGN, Neurilemmoma, Neurinoma, Schwannoma (WHO Grade I)
Parent(s)
Benign Nervous System Neoplasm
Children
Cellular Schwannoma, Acoustic Schwannoma, Schwannomatosis, Sympathetic Schwannoma, Plexiform Schwannoma, Microcystic/Reticular Schwannoma, Trigeminal Schwannoma, Melanotic Schwannoma, and Peripheral Nerve Schwannoma
OncoTree Name
Schwannoma
OncoTree Code
SCHW

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.