Overview

NCI Definition: A myelodysplastic syndrome resulting from chemotherapy or radiation therapy treatment for other malignant disorders. [1]

Significant Genes in Secondary Myelodysplastic Syndrome

ABL1 +

AFF1 +

ASXL1 +

BCR +

DEK +

ELL +

FLT3 +

KMT2A +

MECOM +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

NPM1 +

NRAS +

NUP214 +

RPN1 +

RUNX1 +

SETBP1 +

SF3B1 +

SRSF2 +

TP53 +

U2AF1 +

ZRSR2 +

Disease Details

Parent(s)
Secondary Malignant Neoplasm
Children
Therapy-Related Myelodysplastic Syndrome

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.