NCI Definition: A carcinoma arising from the squamous cells of the epidermis. Skin squamous cell carcinoma is most commonly found on sun-exposed areas. The majority of the tumors are well-differentiated. [1]

Skin squamous cell carcinomas most frequently harbor alterations in TP53, CDKN2A, NOTCH1, KMT2D, and ROS1 [2].

Most Commonly Altered Genes in Skin Squamous Cell Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, NOTCH1 Mutation, and CDKN2A Mutation are the most common alterations in skin squamous cell carcinoma [2].

Top Alterations in Skin Squamous Cell Carcinoma

Significant Genes in Skin Squamous Cell Carcinoma



MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

PMS1 +

PMS2 +

Disease Details

Squamous Cell Carcinoma of Skin, Squamous cell carcinoma - skin, Epidermoid Skin Carcinoma, Epidermoid Carcinoma of Skin, Skin squamous cell carcinoma (SCC), Cutaneous Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Skin, Squamous Cell Skin Carcinoma, Epidermoid Carcinoma of the Skin
Squamous Cell Carcinoma
Skin Pseudovascular Squamous Cell Carcinoma, Scrotal Squamous Cell Carcinoma, Keratoacanthoma, Plantar Verrucous Skin Carcinoma, Cutaneous Squamous Cell Carcinoma of the Head and Neck, Skin Basaloid Carcinoma, Acantholytic Squamous Cell Skin Carcinoma, External Ear Squamous Cell Carcinoma, Skin Squamous Cell Carcinoma In Situ, Clear Cell Squamous Cell Skin Carcinoma, and Spindle Cell (Sarcomatoid) Squamous Cell Skin Carcinoma
OncoTree Name
Cutaneous Squamous Cell Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.