NCI Definition: An adenocarcinoma that arises from the small intestine. Histologic variants include mucinous adenocarcinoma and signet ring cell carcinoma. [1]

Small intestinal adenocarcinomas most frequently harbor alterations in KRAS, TP53, APC, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Small Intestinal Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in small intestinal adenocarcinoma [2].

Top Alterations in Small Intestinal Adenocarcinoma

Significant Genes in Small Intestinal Adenocarcinoma


Disease Details

Adenocarcinoma of Small Intestine, Adenocarcinoma of Small Bowel, Small intestine adenocarcinoma, Adenocarcinoma of the Small Bowel, Adenocarcinoma - small intest., Small Bowel Adenocarcinoma, Adenocarcinoma of the Small Intestine
Small Intestinal Carcinoma
Duodenal Adenocarcinoma and Small Intestinal Mucinous Adenocarcinoma


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.