Overview

NCI Definition: An adenocarcinoma that arises from the small intestine. Histologic variants include mucinous adenocarcinoma and signet ring cell carcinoma. [1]

Small intestinal adenocarcinomas most frequently harbor alterations in TP53, KRAS, APC, PIK3CA, and ERBB2 [2].

Most Commonly Altered Genes in Small Intestinal Adenocarcinoma

TP53 Mutation, KRAS Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and KRAS Exon 2 Mutation are the most common alterations in small intestinal adenocarcinoma [2].

Top Alterations in Small Intestinal Adenocarcinoma

Significant Genes in Small Intestinal Adenocarcinoma

BRAF +

ERBB2 +

Disease Details

Synonyms
Adenocarcinoma of the Small Bowel, Adenocarcinoma - small intest., Small Bowel Adenocarcinoma, Adenocarcinoma of the Small Intestine, Adenocarcinoma of Small Intestine, Small intestine adenocarcinoma, Adenocarcinoma of Small Bowel
Parent(s)
Small Intestinal Carcinoma
Children
Duodenal Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.