Overview

NCI Definition: An adenocarcinoma that arises from the small intestine. Histologic variants include mucinous adenocarcinoma and signet ring cell carcinoma. [1]

Small intestinal adenocarcinomas most frequently harbor alterations in TP53, KRAS, APC, PIK3CA, and ERBB2 [2].

Most Commonly Altered Genes in Small Intestinal Adenocarcinoma

TP53 Mutation, KRAS Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, and KRAS Exon 2 Mutation are the most common alterations in small intestinal adenocarcinoma [2].

Top Alterations in Small Intestinal Adenocarcinoma

Significant Genes in Small Intestinal Adenocarcinoma

BRAF +

ERBB2 +

Disease Details

Synonyms
Small intestine adenocarcinoma, Adenocarcinoma of Small Bowel, Adenocarcinoma of the Small Bowel, Small Bowel Adenocarcinoma, Adenocarcinoma - small intest., Adenocarcinoma of the Small Intestine, Adenocarcinoma of Small Intestine
Parent(s)
Small Intestinal Carcinoma
Children
Duodenal Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.