Overview

NCI Definition: An adenocarcinoma that arises from the small intestine. Histologic variants include mucinous adenocarcinoma and signet ring cell carcinoma. [1]

Small intestinal adenocarcinomas most frequently harbor alterations in KRAS, TP53, APC, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Small Intestinal Adenocarcinoma

KRAS Mutation, KRAS Exon 2 Mutation, KRAS Codon 12 Missense, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in small intestinal adenocarcinoma [2].

Top Alterations in Small Intestinal Adenocarcinoma

Significant Genes in Small Intestinal Adenocarcinoma

BRAF +

Disease Details

Synonyms
Adenocarcinoma of Small Intestine, Adenocarcinoma of the Small Intestine, Small intestine adenocarcinoma, Adenocarcinoma of Small Bowel, Small Bowel Adenocarcinoma, Adenocarcinoma of the Small Bowel, Adenocarcinoma - small intest.
Parent(s)
Small Intestinal Carcinoma
Children
Small Intestinal Mucinous Adenocarcinoma and Duodenal Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.