Overview

NCI Definition: A carcinoma arising from the small intestine. The vast majority are adenocarcinomas. The remaining cases are adenosquamous, squamous, or undifferentiated carcinomas. [1]

Small intestinal carcinomas most frequently harbor alterations in KRAS, APC, TP53, SMAD4, and PIK3CA [2].

Most Commonly Altered Genes in Small Intestinal Carcinoma

KRAS Mutation (somatic), KRAS Mutation (germline), KRAS Mutation, APC Mutation, and TP53 Mutation are the most common alterations in small intestinal carcinoma [2].

Top Alterations in Small Intestinal Carcinoma

Significant Genes in Small Intestinal Carcinoma

ALK +

ERBB2 +

Disease Details

Synonyms
Cancer of Small Bowel, Cancer of the Small Bowel, Carcinoma of Small Intestine, Carcinoma of Small Bowel, Carcinoma of the Small Bowel, Small Bowel Carcinoma, Small intestine cancer, NOS, Carcinoma of the Small Intestine, Small Bowel Cancer, Small Intestine Cancer
Parent(s)
Malignant Small Intestinal Neoplasm
Children
Duodenal Carcinoma and Small Intestinal Adenocarcinoma
OncoTree Name
Small Intestinal Carcinoma
OncoTree Code
SIC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.