NCI Definition: A carcinoma arising from the small intestine. The vast majority are adenocarcinomas. The remaining cases are adenosquamous, squamous, or undifferentiated carcinomas. [1]

Small intestinal carcinomas most frequently harbor alterations in KRAS, TP53, APC, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Small Intestinal Carcinoma

KRAS Mutation, TP53 Mutation, KRAS Exon 2 Mutation, APC Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in small intestinal carcinoma [2].

Top Alterations in Small Intestinal Carcinoma

Significant Genes in Small Intestinal Carcinoma



Disease Details

Carcinoma of the Small Intestine, Cancer of the Small Bowel, Carcinoma of Small Intestine, Carcinoma of the Small Bowel, Carcinoma of Small Bowel, Small Bowel Cancer, Small Intestine Cancer, Cancer of Small Bowel, Small Bowel Carcinoma, Small intestine cancer, NOS
Malignant Small Intestinal Neoplasm
Duodenal Carcinoma and Small Intestinal Adenocarcinoma
OncoTree Name
Small Intestinal Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.