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Small Intestinal Carcinoma

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Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from the small intestine. The vast majority are adenocarcinomas. The remaining cases are adenosquamous, squamous, or undifferentiated carcinomas. [1]

Small intestinal carcinomas most frequently harbor alterations in KRAS, TP53, APC, PIK3CA, and SMAD4 [2].

Most Commonly Altered Genes in Small Intestinal Carcinoma

KRAS Mutation, KRAS Exon 2 Mutation, TP53 Mutation, KRAS Codon 12 Missense, and TP53 c.217-c.1178 Missense are the most common alterations in small intestinal carcinoma [2].

Top Alterations in Small Intestinal Carcinoma

Clinical Trials

View Clinical Trials for Small Intestinal Carcinoma

Significant Genes in Small Intestinal Carcinoma

ALK +

ERBB2 +

Disease Details

Synonyms
Small Bowel Carcinoma, Carcinoma of Small Intestine, Carcinoma of the Small Bowel, Carcinoma of the Small Intestine, Small Bowel Cancer, Cancer of the Small Bowel, Cancer of Small Bowel, Small Intestine Cancer, Small intestine cancer, NOS, Carcinoma of Small Bowel
Parent(s)
Malignant Small Intestinal Neoplasm
Children
Small Intestinal Medullary Carcinoma, Small Intestinal Adenosquamous Carcinoma, Duodenal Carcinoma, Small Intestinal Undifferentiated Carcinoma, Small Intestinal Small Cell Carcinoma, and Small Intestinal Adenocarcinoma
OncoTree Name
Small Intestinal Carcinoma
OncoTree Code
SIC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.