Diseases /

Squamous Cell Carcinoma

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Associated Genetic Biomarkers

Overview

NCI Definition: A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma. [1]

Clinical Trials

View Clinical Trials for Squamous Cell Carcinoma

Significant Genes in Squamous Cell Carcinoma

BRAF +

HRAS +

KRAS +

NRAS +

Disease Details

Synonyms
Squamous Carcinoma, Malignant Squamous Cell Neoplasm, Squamous Cell Epithelioma, Invasive Squamous Cell Carcinoma, Poorly Differentiated Squamous Cell Carcinoma, Malignant Epidermoid Cell Neoplasm, Malignant Squamous Cell Tumor, CARCINOMA, SQUAMOUS CELL, MALIGNANT, Epidermoid Carcinoma, Epidermoid Cell Cancer, Malignant Epidermoid Cell Tumor, Invasive Poorly Differentiated Squamous Cell Carcinoma, Squamous Cell Cancer
Parent(s)
Carcinoma
Children
Tracheal Squamous Cell Carcinoma, Basaloid Squamous Cell Carcinoma, Vulvar/Vaginal Squamous Cell Carcinoma, Ovarian Squamous Cell Carcinoma, Keratinizing Squamous Cell Carcinoma, Ampulla of Vater Squamous Cell Carcinoma, Thymic Squamous Cell Carcinoma, Sarcomatoid Squamous Cell Carcinoma, Conjunctival Squamous Cell Carcinoma, Renal Pelvis Squamous Cell Carcinoma, Colorectal Squamous Cell Carcinoma, Corneal Squamous Cell Carcinoma, Fallopian Tube Squamous Cell Carcinoma, Endometrial Squamous Cell Carcinoma, Extrahepatic Bile Duct Squamous Cell Carcinoma, Thymus Squamous Cell Carcinoma, Urethral Squamous Cell Carcinoma, Pseudoglandular Squamous Cell Carcinoma, Ureter Squamous Cell Carcinoma, Papillary Squamous Cell Carcinoma, Verrucous Carcinoma, Prostate Squamous Cell Carcinoma, Thyroid Gland Squamous Cell Carcinoma, Gastric Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma, Squamous Cell Lung Carcinoma, Squamous Cell Carcinoma of the Penis, Skin Squamous Cell Carcinoma, Squamous Cell Carcinoma of Unknown Primary, Esophageal Squamous Cell Carcinoma, Squamous Cell Breast Carcinoma, Bladder Squamous Cell Carcinoma, Cervical Squamous Cell Carcinoma, Pancreatic Squamous Cell Carcinoma, Gallbladder Squamous Cell Carcinoma, and Anal Squamous Cell Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.