Overview

NCI Definition: A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma. [1]

Squamous cell carcinomas most frequently harbor alterations in TP53, PIK3CA, CDKN2A, KMT2D, and NOTCH1 [2].

Most Commonly Altered Genes in Squamous Cell Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, PIK3CA Mutation, and KMT2D Mutation are the most common alterations in squamous cell carcinoma [2].

Top Alterations in Squamous Cell Carcinoma

Significant Genes in Squamous Cell Carcinoma

BRAF +

HRAS +

KRAS +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

NRAS +

PMS1 +

PMS2 +

Disease Details

Synonyms
Malignant Epidermoid Cell Tumor, Squamous Cell Epithelioma, Squamous Cell Cancer, Malignant Epidermoid Cell Neoplasm, Squamous Carcinoma, Malignant Squamous Cell Tumor, CARCINOMA, SQUAMOUS CELL, MALIGNANT, Malignant Squamous Cell Neoplasm, Epidermoid Cell Cancer, Epidermoid Carcinoma
Parent(s)
Carcinoma
Children
Rectal Squamous Cell Carcinoma, Squamous Cell Carcinoma of Unknown Primary, Ureter Squamous Cell Carcinoma, Thymic Squamous Cell Carcinoma, Squamous Cell Breast Carcinoma, Colon Squamous Cell Carcinoma, Endometrial Squamous Cell Carcinoma, Sarcomatoid Squamous Cell Carcinoma, Pseudoglandular Squamous Cell Carcinoma, Gallbladder Squamous Cell Carcinoma, Prostate Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma, Papillary Squamous Cell Carcinoma, Vulvar/Vaginal Squamous Cell Carcinoma, Esophageal Squamous Cell Carcinoma, Verrucous Carcinoma, Conjunctival Squamous Cell Carcinoma, Metastatic Squamous Cell Carcinoma, Ampulla of Vater Squamous Cell Carcinoma, Extrahepatic Bile Duct Squamous Cell Carcinoma, Renal Pelvis Squamous Cell Carcinoma, Squamous Cell Carcinoma of the Penis, Squamous Cell Lung Carcinoma, Basaloid Squamous Cell Carcinoma, Tracheal Squamous Cell Carcinoma, Fallopian Tube Squamous Cell Carcinoma, Ovarian Squamous Cell Carcinoma, Bladder Squamous Cell Carcinoma, Anal Squamous Cell Carcinoma, Gastric Squamous Cell Carcinoma, Keratinizing Squamous Cell Carcinoma, Thymus Squamous Cell Carcinoma, Urethral Squamous Cell Carcinoma, Cervical Squamous Cell Carcinoma, Skin Squamous Cell Carcinoma, and Corneal Squamous Cell Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.