Associated Genetic Biomarkers

Overview

NCI Definition: A diverse group of carcinomas of the thymus gland, previously known as thymoma type C (WHO-1999). It includes morphologic variants derived from purely epithelial cells, as well as from cells with neuroendocrine differentiation. [1]

Thymic carcinomas most frequently harbor alterations in TP53, CDKN2A, CDKN2B, KMT2D, and CYLD [2].

Most Commonly Altered Genes in Thymic Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 c.142-c.212 Missense, TP53 c.1-c.137 Missense, and TP53 Missense are the most common alterations in thymic carcinoma [2].

Top Alterations in Thymic Carcinoma

Biomarker-Directed Therapies

Significant Genes in Thymic Carcinoma

AKT1 +

AKT2 +

AKT3 +

BRAF +

EGFR +

ERBB2 +

HRAS +

KIT +

KRAS +

NRAS +

NTRK1 +

PDGFRA +

PIK3CA +

PTEN +

Disease Details

Synonyms
Thymic Carcinoma Excluding Well Differentiated Thymic Carcinoma, type C thymoma, Thymic Carcinoma (Excluding Well Differentiated Thymic Carcinoma), Thymoma Type C
Parent(s)
Malignant Thymus Neoplasm
Children
Thymic Large Cell Neuroendocrine Carcinoma, Thymic Lymphoepithelioma-Like Carcinoma, Thymus Squamous Cell Carcinoma, Thymic Clear Cell Carcinoma, Thymus Adenocarcinoma, Thymic Carcinoid Tumor, Thymic Adenocarcinoma, Thymic Mucoepidermoid Carcinoma, Thymic Sarcomatoid Carcinoma, Thymic Small Cell Carcinoma, Thymic Adenosquamous Carcinoma, and Thymic Squamous Cell Carcinoma
OncoTree Name
Thymic Carcinoma
OncoTree Code
THYC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.