Overview

NCI Definition: A diverse group of carcinomas of the thymus gland, previously known as thymoma type C (WHO-1999). It includes morphologic variants derived from purely epithelial cells, as well as from cells with neuroendocrine differentiation. [1]

Thymic carcinomas most frequently harbor alterations in TP53, CDKN2A, CDKN2B, KMT2D, and CYLD [2].

Most Commonly Altered Genes in Thymic Carcinoma

TP53 Mutation, TP53 c.217-c.1178 Missense, TP53 Missense, KMT2D Mutation, and CDKN2B Loss are the most common alterations in thymic carcinoma [2].

Top Alterations in Thymic Carcinoma

Biomarker-Directed Therapies

Significant Genes in Thymic Carcinoma

AKT1 +

AKT2 +

AKT3 +

BRAF +

EGFR +

ERBB2 +

HRAS +

KIT +

KRAS +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

NRAS +

NTRK1 +

PDGFRA +

PIK3CA +

PMS1 +

PMS2 +

PTEN +

Disease Details

Synonyms
Thymic Carcinoma (Excluding Well Differentiated Thymic Carcinoma), Thymoma Type C, Thymus carcinoma (NOS), Thymic Carcinoma Excluding Well Differentiated Thymic Carcinoma, type C thymoma
Parent(s)
Malignant Thymus Neoplasm
Children
Thymic Squamous Cell Carcinoma, Thymic Lymphoepithelioma-Like Carcinoma, Thymic Adenocarcinoma, Thymic Adenosquamous Carcinoma, Thymic Mucoepidermoid Carcinoma, Thymic Small Cell Carcinoma, Thymic Sarcomatoid Carcinoma, Thymic Carcinoid Tumor, Thymus Adenocarcinoma, Thymic Clear Cell Carcinoma, Thymus Squamous Cell Carcinoma, and Thymic Large Cell Neuroendocrine Carcinoma
OncoTree Name
Thymic Carcinoma
OncoTree Code
THYC

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.