Overview

NCI Definition: An adenocarcinoma arising from the follicular cells of the thyroid gland. According to the degree of differentiation, it is classified either as differentiated carcinoma (extensive evidence of follicular cell differentiation), or poorly differentiated carcinoma (limited evidence of follicular cell differentiation). [1]

Thyroid gland adenocarcinomas most frequently harbor alterations in BRAF, NRAS, TP53, HRAS, and ATM [2].

Most Commonly Altered Genes in Thyroid Gland Adenocarcinoma

BRAF Mutation, BRAF Exon 15 Mutation, BRAF V600E, BRAF Codon 600 Missense, and NRAS Mutation are the most common alterations in thyroid gland adenocarcinoma [2].

Top Alterations in Thyroid Gland Adenocarcinoma

Significant Genes in Thyroid Gland Adenocarcinoma

BRAF +

Disease Details

Parent(s)
Adenocarcinoma
Children
Poorly Differentiated Thyroid Gland Carcinoma and Well-Differentiated Thyroid Gland Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.