Overview

NCI Definition: A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic. [1]

Biomarker-Directed Therapies

Significant Genes in Thyroid Gland Carcinoma

AKT1 +

AKT2 +

AKT3 +

ALK +

ARAF +

BRAF +

CRKL +

HRAS +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MTOR +

NF1 +

NRAS +

PAX8 +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PPARG +

PTEN +

RAF1 +

RET +

RICTOR +

RPTOR +

SRC +

STK11 +

TSC1 +

TSC2 +

Disease Details

Synonyms
Cancer of Thyroid, thyroid cancer, Carcinoma of Thyroid, Thyroid Cancer, Carcinoma of the Thyroid, Thyroid Carcinoma, Head and Neck Cancer, Thyroid, Thyroid carcinoma (NOS), Thyroid Gland Cancer, Carcinoma of Thyroid Gland, Thyroid cancer, NOS, Carcinoma of the Thyroid Gland, Cancer of the Thyroid
Parent(s)
Malignant Thyroid Gland Neoplasm
Children
Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Thyroid Gland Medullary Carcinoma, Thyroid Gland Adenocarcinoma, Thyroid Gland Squamous Cell Carcinoma, and Thyroid Gland Mucoepidermoid Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.