Overview

NCI Definition: A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic. [1]

Thyroid gland carcinomas most frequently harbor alterations in RET, TP53, BRAF, NRAS, and CDKN2A [2].

Most Commonly Altered Genes in Thyroid Gland Carcinoma

RET Mutation, RET M918T, TP53 Mutation, TP53 c.217-c.1178 Missense, and TP53 c.142-c.212 Missense are the most common alterations in thyroid gland carcinoma [2].

Top Alterations in Thyroid Gland Carcinoma

Significant Genes in Thyroid Gland Carcinoma

AKT1 +

AKT2 +

AKT3 +

ALK +

ARAF +

BRAF +

CRKL +

EGFR +

ERBB2 +

HRAS +

IRS2 +

KIT +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MET +

MLH1 +

MSH2 +

MSH6 +

MTOR +

NF1 +

NRAS +

PAX8 +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS2 +

PPARG +

PTEN +

RAF1 +

RET +

RICTOR +

RNF43 +

RPTOR +

SRC +

STK11 +

TSC1 +

TSC2 +

Disease Details

Synonyms
Thyroid Carcinoma, Carcinoma of Thyroid, Carcinoma of the Thyroid, thyroid cancer, Carcinoma of the Thyroid Gland, Thyroid Cancer, Thyroid Gland Cancer, Cancer of Thyroid, Head and Neck Cancer, Thyroid, Carcinoma of Thyroid Gland, Thyroid cancer, NOS, Cancer of the Thyroid
Parent(s)
Malignant Thyroid Gland Neoplasm
Children
Thyroid Gland Adenocarcinoma, Thyroid Gland Mucoepidermoid Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, and Thyroid Gland Medullary Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.