Overview

NCI Definition: A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic. [1]

Thyroid gland carcinomas most frequently harbor alterations in BRAF, NRAS, TP53, RET, and HRAS [2].

Most Commonly Altered Genes in Thyroid Gland Carcinoma

BRAF Mutation, BRAF Exon 15 Mutation, BRAF V600E, BRAF Codon 600 Missense, and NRAS Mutation are the most common alterations in thyroid gland carcinoma [2].

Top Alterations in Thyroid Gland Carcinoma

Biomarker-Directed Therapies

Significant Genes in Thyroid Gland Carcinoma

AKT1 +

AKT2 +

AKT3 +

ALK +

ARAF +

BRAF +

CRKL +

EGFR +

ERBB2 +

HRAS +

IRS2 +

KIT +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MET +

MLH1 +

MLH3 +

MSH2 +

MSH3 +

MSH6 +

MTOR +

NF1 +

NRAS +

PAX8 +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PMS1 +

PMS2 +

PPARG +

PTEN +

RAF1 +

RET +

RICTOR +

RNF43 +

RPTOR +

SRC +

STK11 +

TSC1 +

TSC2 +

Disease Details

Synonyms
Thyroid Gland Cancer, Head and Neck Cancer, Thyroid, Carcinoma of Thyroid, thyroid cancer, Thyroid Carcinoma, Carcinoma of the Thyroid Gland, Carcinoma of Thyroid Gland, Cancer of the Thyroid, Carcinoma of the Thyroid, Thyroid carcinoma (NOS), Cancer of Thyroid, Thyroid Cancer, Thyroid cancer, NOS
Parent(s)
Malignant Thyroid Gland Neoplasm
Children
Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, Thyroid Gland Mucoepidermoid Carcinoma, Thyroid Gland Adenocarcinoma, and Thyroid Gland Medullary Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.