Overview

NCI Definition: A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic. [1]

Thyroid gland carcinomas most frequently harbor alterations in BRAF, RET, TP53, NRAS, and CDKN2A [2].

Most Commonly Altered Genes in Thyroid Gland Carcinoma

BRAF Mutation, BRAF Exon 15 Mutation, BRAF Codon 600 Missense, BRAF V600E, and NRAS Mutation are the most common alterations in thyroid gland carcinoma [2].

Top Alterations in Thyroid Gland Carcinoma

Biomarker-Directed Therapies

Significant Genes in Thyroid Gland Carcinoma

AKT1 +

AKT2 +

AKT3 +

ALK +

ARAF +

BRAF +

CRKL +

HRAS +

KRAS +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MTOR +

NF1 +

NRAS +

PAX8 +

PDGFRA +

PIK3CA +

PIK3CG +

PIK3R1 +

PIK3R2 +

PPARG +

PTEN +

RAF1 +

RET +

RICTOR +

RPTOR +

SRC +

STK11 +

TSC1 +

TSC2 +

Disease Details

Synonyms
Carcinoma of Thyroid Gland, Thyroid cancer, NOS, Thyroid carcinoma (NOS), Cancer of the Thyroid, Thyroid Gland Cancer, Thyroid Cancer, Head and Neck Cancer, Thyroid, thyroid cancer, Carcinoma of Thyroid, Thyroid Carcinoma, Carcinoma of the Thyroid, Cancer of Thyroid, Carcinoma of the Thyroid Gland
Parent(s)
Malignant Thyroid Gland Neoplasm
Children
Thyroid Gland Mucoepidermoid Carcinoma, Thyroid Gland Adenocarcinoma, Thyroid Gland Squamous Cell Carcinoma, Thyroid Gland Undifferentiated (Anaplastic) Carcinoma, and Thyroid Gland Medullary Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.