Overview

NCI Definition: A differentiated adenocarcinoma arising from the follicular cells of the thyroid gland. Radiation exposure is a risk factor and it is the most common malignant thyroid lesion, comprising 75% to 80% of all thyroid cancers in iodine sufficient countries. Diagnostic procedures include thyroid ultrasound and fine needle biopsy. Microscopically, the diagnosis is based on the distinct characteristics of the malignant cells, which include enlargement, oval shape, elongation, and overlapping of the nuclei. The nuclei also display clearing or have a ground glass appearance. [1]

Thyroid gland papillary carcinomas most frequently harbor alterations in BRAF, NRAS, HRAS, ATM, and TP53 [2].

Most Commonly Altered Genes in Thyroid Gland Papillary Carcinoma

BRAF Mutation, BRAF V600E, BRAF Codon 600 Missense, NRAS Mutation (somatic), and NRAS Mutation (germline) are the most common alterations in thyroid gland papillary carcinoma [2].

Top Alterations in Thyroid Gland Papillary Carcinoma

Significant Genes in Thyroid Gland Papillary Carcinoma

BRAF +

HRAS +

KRAS +

NRAS +

RET +

Disease Details

Synonyms
Papillary Thyroid Cancer, Papillary Cancer of the Thyroid, Papillary Carcinoma of Thyroid
Parent(s)
Well-Differentiated Thyroid Gland Carcinoma
Children
Multicentric Thyroid Gland Papillary Carcinoma, Thyroid Gland Diffuse Sclerosing Papillary Carcinoma, Tall Cell Variant Thyroid Gland Papillary Carcinoma, Columnar Cell Variant Thyroid Gland Papillary Carcinoma, and Follicular Variant Thyroid Gland Papillary Carcinoma
OncoTree Name
Papillary Thyroid Cancer
OncoTree Code
THPA

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.