Overview

NCI Definition: A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries. [1]

Transitional cell carcinomas most frequently harbor alterations in TP53, KMT2D, KDM6A, FGFR3, and ARID1A [2].

Most Commonly Altered Genes in Transitional Cell Carcinoma

TP53 Mutation, TP53 Missense, TP53 c.217-c.1178 Missense, KMT2D Mutation, and KDM6A Mutation are the most common alterations in transitional cell carcinoma [2].

Top Alterations in Transitional Cell Carcinoma

Significant Genes in Transitional Cell Carcinoma

BRCA1 +

BRCA2 +

ERBB2 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

TP53 +

TSC1 +

TSC2 +

Disease Details

Synonyms
CARCINOMA, TRANSITIONAL CELL, MALIGNANT, Transitional Carcinoma
Parent(s)
Transitional Cell Neoplasm
Children
Papillary Transitional Cell Carcinoma, Sarcomatoid Transitional Cell Carcinoma, Primary Peritoneal Transitional Cell Carcinoma, Bartholin Gland Transitional Cell Carcinoma, Urothelial Carcinoma, Ovarian Transitional Cell Carcinoma, Endometrial Transitional Cell Carcinoma, and Fallopian Tube Transitional Cell Carcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.