Overview

NCI Definition: A transitional cell carcinoma that arises from the male or female urethra. [1]

Urethral urothelial carcinomas most frequently harbor alterations in TP53, KDM6A, FGFR3, PIK3CA, and ARID1A [2].

Most Commonly Altered Genes in Urethral Urothelial Carcinoma

TP53 Mutation, KDM6A Mutation, FGFR3 Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in urethral urothelial carcinoma [2].

Top Alterations in Urethral Urothelial Carcinoma

Significant Genes in Urethral Urothelial Carcinoma

FGFR1 +

FGFR3 +

TSC1 +

TSC2 +

Disease Details

Synonyms
Transitional Cell Carcinoma of the Urethra, Urethral Transitional Cell Carcinoma, Urethra Transitional Cell Carcinoma, Transitional Cell Carcinoma of Urethra
Parent(s)
Urothelial Carcinoma
Children
Prostatic Urethra Urothelial Carcinoma
OncoTree Name
Urethral Urothelial Carcinoma
OncoTree Code
UCU

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.