NCI Definition: A transitional cell carcinoma that arises from the male or female urethra. [1]

Urethral urothelial carcinomas most frequently harbor alterations in TP53, FGFR3, KDM6A, PIK3CA, and CDKN2A [2].

Most Commonly Altered Genes in Urethral Urothelial Carcinoma

TP53 Mutation, TP53 Missense, FGFR3 Mutation, TP53 c.217-c.1178 Missense, and FGFR3 S249C are the most common alterations in urethral urothelial carcinoma [2].

Top Alterations in Urethral Urothelial Carcinoma

Significant Genes in Urethral Urothelial Carcinoma




TSC1 +

TSC2 +

Disease Details

Transitional Cell Carcinoma of Urethra, Urethral Transitional Cell Carcinoma, Transitional Cell Carcinoma of the Urethra, Urethra Transitional Cell Carcinoma
Urothelial Carcinoma
Prostatic Urethra Urothelial Carcinoma
OncoTree Name
Urethral Urothelial Carcinoma
OncoTree Code


1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.