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Vaginal Adenocarcinoma

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Associated Genetic Biomarkers

Overview

NCI Definition: An adenocarcinoma arising from the vagina. Morphologic variants include the clear cell, endometrioid, mesonephric, and mucinous adenocarcinoma. [1]

Vaginal adenocarcinomas most frequently harbor alterations in TP53, LZTR1, FANCA, and ATM [2].

Most Commonly Altered Genes in Vaginal Adenocarcinoma

TP53 c.217-c.1178 Missense, TP53 Y163N, TP53 Mutation, TP53 Missense, and TP53 Exon 5 Mutation are the most common alterations in vaginal adenocarcinoma [2].

Top Alterations in Vaginal Adenocarcinoma

Clinical Trials

View Clinical Trials for Vaginal Adenocarcinoma

Disease Details

Synonyms
Vagina adenocarcinoma
Parent(s)
Vulvar/Vaginal Adenocarcinoma
Children
Vaginal Endometrioid Adenocarcinoma, Vaginal Mucinous Adenocarcinoma, and Vaginal Clear Cell Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.