Associated Genetic Biomarkers

Overview

NCI Definition: An adenocarcinoma arising from the vagina. Morphologic variants include the clear cell, endometrioid, mesonephric, and mucinous adenocarcinoma. [1]

Vaginal adenocarcinomas most frequently harbor alterations in TP53, LZTR1, FANCA, and ATM [2].

Most Commonly Altered Genes in Vaginal Adenocarcinoma

TP53 c.217-c.1178 Missense, TP53 Y163N, TP53 Mutation, TP53 Missense, and TP53 Exon 5 Mutation are the most common alterations in vaginal adenocarcinoma [2].

Top Alterations in Vaginal Adenocarcinoma

Disease Details

Synonyms
Vagina adenocarcinoma
Parent(s)
Vaginal Glandular Neoplasm
Children
Vaginal Endometrioid Adenocarcinoma and Vaginal Mucinous Adenocarcinoma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.