Overview

NCI Definition: A glioma arising from the central nervous system. This category includes diffuse astrocytoma, ependymoma, oligodendroglioma, and oligoastrocytoma. [1]

WHO grade II gliomas most frequently harbor alterations in IDH1, CIC, TP53, NOTCH1, and PIK3CA [2].

Most Commonly Altered Genes in WHO Grade II Glioma

IDH1 Mutation, IDH1 Codon 132 Missense, IDH1 R132H, TP53 Mutation, and TP53 c.217-c.1178 Missense are the most common alterations in WHO grade II glioma [2].

Top Alterations in WHO Grade II Glioma

Significant Genes in WHO Grade II Glioma

IDH1 +

IDH2 +

PDGFA +

PDGFB +

PDGFRA +

PDGFRB +

Disease Details

Parent(s)
Low Grade Glioma
Children
Diffuse Astrocytoma, Ependymoma, Oligoastrocytoma, and Oligodendroglioma

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.