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estradiol

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Associated Genetic Biomarkers

Overview

NCI Definition [1]:
The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol.

Clinical Trials

View Clinical Trials for estradiol

Estradiol has been investigated in 3 clinical trials, of which 3 are open and 0 are closed. Of the trials investigating estradiol, 3 are phase 2 (3 open).

HER2 Deficient Expression, HER2 Negative, and ER Positive are the most frequent biomarker inclusion criteria for estradiol clinical trials.

Breast carcinoma is the most common disease being investigated in estradiol clinical trials [2].

Top Biomarker Inclusion Criteria for Open Clinical Trials Investigating Estradiol
This graph displays the 20 most frequently occurring biomarkers curated on clinical trials investigating estradiol and the cancer types associated with these biomarkers. These numbers are derived from a set of 5,956 clinical trials for which biomarker status defines treatment.

Drug Details

Synonyms [2]:
estradiol 17-beta, 17 beta-oestradiol, estradiol 17 beta, 17 beta-estradiol, dihydrotheelin, oestradiol, dihydrofolliculin, estradiol-17beta, estradiol a 017 beta, dihydrofollicular hormone, cis-estradiol, estradiol anhydrous, dihydroxyestrin, e2 - estradiol, benzhormovarine, estradiol (substance), 17-beta oestradiol, 17beta oestradiol, 17beta-oestradiol, beta estradiol 17, estra-1,3,5(10)-triene-3,17-diol (17beta)-, 17beta-estra-1,3,5(10)-triene-3,17-diol, estradiol-17 beta, estradiolum, estradiol [chemical/ingredient], beta-estradiol, estradiol 17beta, 17 beta oestradiol, 17-beta-estradiol, estradiol, 17 beta-estradiol, e2 - oestradiol, 17 beta estradiol, (17beta)-estra-1,3,5(10)-triene-3,17-diol, estradiol, 17-beta estradiol
Drug Categories [2]:
Estrogen receptor antagonists
NCIT ID [1]:
C2295
SNOMED ID [1]:
C-A05AB

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.