Associated Genetic Biomarkers

Overview

Generic Name(s):
flutamide
Trade Name(s):
Flulem, Flutamex, Flutamin, Prostogenat, Tafenil, Chimax, Fluken, Fluta-Gry, Flutaplex, Prostacur, Oncosal, Apimid, Tecnoflut, Euflex, Flucinome, Prostica, Fugerel, Grisetin, Eulexin, Profamid, Eulexine, Drogenil, Flutan, Flutacan, Testotard, Prostadirex, and Flutabene
NCI Definition [1]:
A toluidine derivative and a nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)

Flutamide has been investigated in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial investigating flutamide, 1 is early phase 1 (1 open).

Prostate carcinoma is the most common disease being investigated in flutamide clinical trials [2].

Drug Details

Synonyms [2]:
Eulexin, Apimid, Chimax, Drogenil, Euflex, Eulexine, Flucinome, Fluken, Flulem, Flutabene, Flutacan, Fluta-Gry, Flutamex, Flutamin, Flutan, Flutaplex, Fugerel, Grisetin, Oncosal, Profamid, Prostacur, Prostadirex, Prostica, Prostogenat, Tafenil, Tecnoflut, Testotard, 4'-nitro-3'-trifluoromethylisobutyranilide, alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide, sch13521, sch 13521, flutamide, flutamida, 25378, nfba, propanamide, 2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)-, fluta gry, 2-methyl-n-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, 4'-nitro-3'-trifluoromethylisobutyranilide, fluta-gry, 147834, flutamide (substance), cytomid, 215876, flutamide (product), alpha,alpha,alpha-trifluoro-2-methyl-4'-nitro-m-propionotoluidide, testac, flutamidum, flut, sch-13521, 2-methyl-n-[4-nitro-3-(trifluoromethyl)phenyl]propanamide, sch 13521, fta, niftolide, cebatrol, flutamid, flutagry, flugerel, flutamide, alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide, flucinom, flutamide [chemical/ingredient], niftolid, 13311-84-7, propanamide, 2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)-
Drug Categories [2]:
Androgen receptor antagonists
Drug Target(s) [2]:
AR
NCIT ID [1]:
C509
SNOMED ID [1]:
C-A3120

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/. [2018-07-30] [2018-08-02].

2. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.