Overview

Location [1]
14q32.33
Pathway
PI3K/AKT1/MTOR
Protein [2]
RAC-alpha serine/threonine-protein kinase
Synonyms [1]
AKT, RAC-ALPHA, PKB-ALPHA, RAC, CWS6, PKB, PRKBA

AKT1 (v-akt murine thymoma viral oncogene homolog 1) is a gene that encodes for the protein RAC-alpha serine/threonine-protein kinase. AKT1 plays a key role in multiple cell processes, including growth, proliferation, survival, and angiogenesis. AKT1 mutations are observed in many cancer types.

AKT1 is altered in 1.80% of all cancers with breast carcinoma, colorectal adenocarcinoma, non-small cell lung carcinoma, uterine corpus neoplasm, and melanoma having the greatest prevalence of alterations [3].

AKT1 GENIE Cases - Top Diseases

The most common alterations in AKT1 are AKT1 Mutation (2.09%), AKT1 Mutation (somatic) (2.09%), AKT1 E17K (1.26%), AKT1 Amplification (0.30%), and AKT1 Loss (0.07%) [3].

AKT1 GENIE Cases - Top Alterations

Significance of AKT1 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Endometrial Carcinoma +

Non-Hodgkin Lymphoma +

Squamous Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Prostate Carcinoma +

Cancer +

Multiple Myeloma +

Thyroid Gland Carcinoma +

Thymic Carcinoma +

Gastric Adenocarcinoma +

Colorectal Carcinoma +

Melanoma +

Glioblastoma +

Small Cell Lung Carcinoma +

Lymphoma +

Cholangiocarcinoma +

Renal Cell Carcinoma +

Hepatocellular Carcinoma +

Pancreatic Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Histiocytic And Dendritic Cell Neoplasm +

Ovarian Carcinoma +

Peritoneal Mesothelioma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.