Overview

Location [1]
19q13.2
Pathway
PI3K/AKT1/MTOR
Protein [2]
RAC-beta serine/threonine-protein kinase
Synonyms [1]
PKBB, PRKBB, PKBBETA, HIHGHH, RAC-BETA

V-akt murine thymoma viral oncogene homolog 2 (AKT2) is a gene that encodes a protein serine/threonine kinase with a SH2-like domain. Missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

AKT2 is altered in 1.54% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, pancreatic adenocarcinoma, high grade ovarian serous adenocarcinoma, and colon adenocarcinoma having the greatest prevalence of alterations [3].

AKT2 GENIE Cases - Top Diseases

The most common alterations in AKT2 are AKT2 Amplification (0.96%), AKT2 Mutation (0.61%), AKT2 Loss (0.09%), AKT2 E17K (0.04%), and AKT2 Fusion (0.05%) [3].

AKT2 GENIE Cases - Top Alterations

Significance of AKT2 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Small Cell Lung Carcinoma +

Squamous Cell Lung Carcinoma +

Melanoma +

Hepatocellular Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Renal Cell Carcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Liposarcoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Osteosarcoma +

Cancer +

Glioblastoma +

Undifferentiated Pleomorphic Sarcoma +

Chondrosarcoma +

Thyroid Gland Carcinoma +

Gastric Adenocarcinoma +

Myelodysplastic Syndromes +

Cholangiocarcinoma +

B-Cell Non-Hodgkin Lymphoma +

Hematopoietic And Lymphoid Malignancy +

Myeloid Neoplasm +

Hematopoietic And Lymphoid System Neoplasm +

Hematologic And Lymphocytic Disorder +

Aggressive Systemic Mastocytosis +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Ewing Sarcoma +

Histiocytic And Dendritic Cell Neoplasm +

Mast Cell Leukemia +

Multiple Myeloma +

Pecoma +

Peritoneal Mesothelioma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thymic Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.