Location [1]
Protein [2]
Baculoviral IAP repeat-containing protein 5
Synonyms [1]

BIRC5 is altered in 0.21% of all cancers with bladder urothelial carcinoma and gallbladder carcinoma having the greatest prevalence of alterations [3].

BIRC5 GENIE Cases - Top Diseases

The most common alterations in BIRC5 are BIRC5 A128V (0.20%), BIRC5 L98V (0.22%), and BIRC5 R132H (0.20%) [3].

BIRC5 GENIE Cases - Top Alterations

Significance of BIRC5 in Diseases

Malignant Solid Tumor +

Urothelial Carcinoma +

Bladder Carcinoma +

Burkitt Lymphoma +

Colorectal Carcinoma +

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Endometrial Endometrioid Adenocarcinoma +

Endometrial Serous Adenocarcinoma +

Fallopian Tube Carcinoma +

Gastric Carcinoma +

Gastrointestinal Neuroendocrine Tumors +

Glioblastoma +

Hepatocellular Carcinoma +

Lung Neuroendocrine Neoplasm +

Malignant Ovarian Epithelial Tumor +

Non-Small Cell Lung Carcinoma +

Pancreatic Neuroendocrine Tumor +

Primary Peritoneal Carcinoma +

Transformed Non-Hodgkin Lymphoma +

Uterine Corpus Carcinosarcoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.