Location [1]
Protein [2]
Synonyms [1]
SSA, HEL-S-99n, CRT, RO, cC1qR

Calreticulin (CALR) is a calcium-binding protein that functions in calcium storage and transcription regulation. Missense mutations, silent mutations, nonsense mutations, and frameshift insertions and deletions are observed in cancers such as colorectal cancer, leukemias, myeloproliferative neoplasms, and stomach cancer.

CALR is altered in 1.22% of all cancers with myeloproliferative neoplasm, high grade ovarian serous adenocarcinoma, lung adenocarcinoma, essential thrombocythemia, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

CALR GENIE Cases - Top Diseases

The most common alterations in CALR are CALR Mutation (0.85%), CALR Amplification (0.33%), CALR L367fs (1.13%), CALR K385fs (0.53%), and CALR Loss (0.06%) [3].

CALR GENIE Cases - Top Alterations

Significance of CALR in Diseases

Myelofibrosis +

Multiple Myeloma +

Plasma Cell Leukemia +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.