Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
7q36.3
Protein [2]
Motor neuron and pancreas homeobox protein 1
Synonyms [1]
HB9, HOXHB9, SCRA1, HLXB9

Motor neuron and pancreas homeobox 1 (MNX1) is a gene that encodes a nuclear protein that functions as a transcription factor that is involved in pancreas development and function. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

MNX1 is altered in 0.15% of all cancers with breast invasive ductal carcinoma, high grade ovarian serous adenocarcinoma, invasive breast carcinoma, lung adenocarcinoma, and appendix adenocarcinoma having the greatest prevalence of alterations [3].

MNX1 GENIE Cases - Top Diseases

The most common alterations in MNX1 are MNX1 A192S (1.85%), MNX1 A23T (0.39%), MNX1 E326G (0.22%), MNX1 G49del (0.39%), and MNX1 L30S (0.22%) [3].

MNX1 GENIE Cases - Top Alterations

Significance of MNX1 in Diseases

Acute Biphenotypic Leukemia +

Acute Erythroid Leukemia +

Acute Lymphoblastic Leukemia +

Acute Megakaryoblastic Leukemia +

Acute Myeloid Leukemia +

Acute Undifferentiated Leukemia +

Chronic Myeloid Leukemia +

Hodgkin Lymphoma +

Juvenile Myelomonocytic Leukemia +

Myelodysplastic Syndromes +

Myeloid Sarcoma +

Natural Killer Cell Lymphoblastic Leukemia/Lymphoma +

Non-Hodgkin Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.