Overview

Location [1]
1q25.2
Synonyms [1]
ARG, ABLL

ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2) is a gene that encodes a protein non-receptor tyrosine kinase. The protein functions in cytoskeletal rearrangements. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift insertions and deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Significance of ABL2 in Diseases

Acute Lymphoblastic Leukemia +

B-Cell Acute Lymphoblastic Leukemia +

Acute Myeloid Leukemia +

Mixed Phenotype Acute Leukemia +

Myelodysplastic Syndromes +

Anaplastic Astrocytoma +

B-Cell Lymphoblastic Lymphoma +

Bladder Carcinoma +

Breast Carcinoma +

Chronic Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Colorectal Carcinoma +

Glioblastoma +

Head And Neck Carcinoma +

Lymphoblastic Lymphoma +

Lymphoma +

Malignant Solid Tumor +

Melanoma +

Mixed Phenotype Acute Leukemia, B/Myeloid, NOS +

Mixed Phenotype Acute Leukemia, T/Myeloid, NOS +

Non-Small Cell Lung Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Sarcoma +

Secondary Acute Myeloid Leukemia +

T-Cell Acute Lymphoblastic Leukemia +

T-Cell Lymphoblastic Lymphoma +

Therapy-Related Acute Myeloid Leukemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.