Overview

Location [1]
14q32.33
Pathway
PI3K/AKT1/MTOR
Protein [2]
RAC-alpha serine/threonine-protein kinase
Synonyms [1]
PKB, PRKBA, CWS6, PKB-ALPHA, RAC, AKT, RAC-ALPHA

AKT1 (v-akt murine thymoma viral oncogene homolog 1) is a gene that encodes for the protein RAC-alpha serine/threonine-protein kinase. AKT1 plays a key role in multiple cell processes, including growth, proliferation, survival, and angiogenesis. AKT1 mutations are observed in many cancer types.

AKT1 is altered in 1.60% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and invasive breast carcinoma having the greatest prevalence of alterations [3].

AKT1 GENIE Cases - Top Diseases

The most common alterations in AKT1 are AKT1 Mutation (2.09%), AKT1 E17K (1.26%), AKT1 Amplification (0.30%), AKT1 Loss (0.07%), and AKT1 L52R (0.04%) [3].

AKT1 GENIE Cases - Top Alterations

Significance of AKT1 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Endometrial Carcinoma +

Cancer +

Gastric Adenocarcinoma +

Squamous Cell Lung Carcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Renal Cell Carcinoma +

Pancreatic Carcinoma +

Hepatocellular Carcinoma +

Multiple Myeloma +

Small Cell Lung Carcinoma +

Breast Adenocarcinoma +

Malignant Uterine Neoplasm +

Urothelial Carcinoma +

Bladder Carcinoma +

Thyroid Gland Carcinoma +

Glioblastoma +

Lung Carcinoma +

Lymphoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Aggressive Systemic Mastocytosis +

B-Cell Non-Hodgkin Lymphoma +

Bile Duct Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Cholangiocarcinoma +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Ewing Sarcoma +

Gallbladder Carcinoma +

Head And Neck Carcinoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Liposarcoma +

Mast Cell Leukemia +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Oropharyngeal Squamous Cell Carcinoma +

Osteosarcoma +

Pecoma +

Peritoneal Mesothelioma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thymic Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.