Biomarkers /
AKT1
Overview
AKT1 (v-akt murine thymoma viral oncogene homolog 1) is a gene that encodes for the protein RAC-alpha serine/threonine-protein kinase. AKT1 plays a key role in multiple cell processes, including growth, proliferation, survival, and angiogenesis. AKT1 mutations are observed in many cancer types.
AKT1 is altered in 1.78% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, lung adenocarcinoma, and invasive breast carcinoma having the greatest prevalence of alterations [3].
The most common alterations in AKT1 are AKT1 Mutation (1.48%), AKT1 E17K (0.87%), AKT1 Amplification (0.28%), AKT1 Loss (0.11%), and AKT1 L52R (0.06%) [3].
Clinical Trials
Significance of AKT1 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.