Overview

Location [1]
19q13.2
Pathway
PI3K/AKT1/MTOR
Protein [2]
RAC-beta serine/threonine-protein kinase
Synonyms [1]
PKBB, HIHGHH, PRKBB, RAC-BETA, PKBBETA

V-akt murine thymoma viral oncogene homolog 2 (AKT2) is a gene that encodes a protein serine/threonine kinase with a SH2-like domain. Missense mutations, nonsense mutations, silent mutations, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

AKT2 is altered in 1.35% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, high grade ovarian serous adenocarcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

AKT2 GENIE Cases - Top Diseases

The most common alterations in AKT2 are AKT2 Amplification (0.95%), AKT2 Mutation (0.70%), AKT2 Loss (0.04%), AKT2 E17K (0.03%), and AKT2 D416N (0.01%) [3].

AKT2 GENIE Cases - Top Alterations

Significance of AKT2 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Squamous Cell Lung Carcinoma +

Small Cell Lung Carcinoma +

Melanoma +

Renal Cell Carcinoma +

Prostate Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Hepatocellular Carcinoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Liposarcoma +

Urothelial Carcinoma +

Endometrial Carcinoma +

Thyroid Gland Carcinoma +

Glioblastoma +

Cancer +

Aggressive Systemic Mastocytosis +

B-Cell Non-Hodgkin Lymphoma +

Cholangiocarcinoma +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Ewing Sarcoma +

Gastric Adenocarcinoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Mast Cell Leukemia +

Multiple Myeloma +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Osteosarcoma +

Pecoma +

Peritoneal Mesothelioma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thymic Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.