Location [1]
Protein [2]
RAC-gamma serine/threonine-protein kinase
Synonyms [1]

V-akt murine thymoma viral oncogene homolog 2 (AKT3) is a gene that encodes a protein serine/threonine kinase that plays a role in insulin and growth factor signaling. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

AKT3 is altered in 1.27% of all cancers with non-small cell lung carcinoma, breast carcinoma, colorectal adenocarcinoma, uterine corpus neoplasm, and melanoma having the greatest prevalence of alterations [3].

AKT3 GENIE Cases - Top Diseases

The most common alterations in AKT3 are AKT3 Mutation (0.95%), AKT3 Mutation (somatic) (0.95%), AKT3 Amplification (0.30%), AKT3 Loss (0.04%), and AKT3 E17K (0.03%) [3].

AKT3 GENIE Cases - Top Alterations

Significance of AKT3 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Non-Hodgkin Lymphoma +

Endometrial Carcinoma +

Squamous Cell Lung Carcinoma +

Prostate Carcinoma +

Ovarian Carcinoma +

Colorectal Carcinoma +

Peritoneal Mesothelioma +

Melanoma +

Small Cell Lung Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Gastric Adenocarcinoma +

Pancreatic Carcinoma +

Malignant Glioma +

Glioblastoma +

Thyroid Gland Carcinoma +

Cholangiocarcinoma +

Hepatocellular Carcinoma +

Renal Cell Carcinoma +

B-Cell Non-Hodgkin Lymphoma +

Cancer +

Histiocytic And Dendritic Cell Neoplasm +

Multiple Myeloma +

Thymic Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.