Overview

Location [1]
1q43-q44
Pathway
PI3K/AKT1/MTOR
Protein [2]
RAC-gamma serine/threonine-protein kinase
Synonyms [1]
MPPH2, PKBG, MPPH, PKB-GAMMA, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2

V-akt murine thymoma viral oncogene homolog 2 (AKT3) is a gene that encodes a protein serine/threonine kinase that plays a role in insulin and growth factor signaling. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

AKT3 is altered in 1.24% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and invasive breast carcinoma having the greatest prevalence of alterations [3].

AKT3 GENIE Cases - Top Diseases

The most common alterations in AKT3 are AKT3 Mutation (0.83%), AKT3 Amplification (0.31%), AKT3 Loss (0.08%), AKT3 E17K (0.03%), and AKT3 L51R (0.02%) [3].

AKT3 GENIE Cases - Top Alterations

Significance of AKT3 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Melanoma +

Head And Neck Squamous Cell Carcinoma +

Small Cell Lung Carcinoma +

Squamous Cell Lung Carcinoma +

Prostate Carcinoma +

Hepatocellular Carcinoma +

Renal Cell Carcinoma +

Endometrial Carcinoma +

Pecoma +

Peritoneal Mesothelioma +

Urothelial Carcinoma +

Gastric Adenocarcinoma +

Multiple Myeloma +

B-Cell Non-Hodgkin Lymphoma +

Cancer +

Osteosarcoma +

Cholangiocarcinoma +

Malignant Glioma +

Pancreatic Carcinoma +

Ovarian Carcinoma +

Glioblastoma +

Hematologic And Lymphocytic Disorder +

Undifferentiated Pleomorphic Sarcoma +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Liposarcoma +

Thyroid Gland Carcinoma +

Myeloid Neoplasm +

Aggressive Systemic Mastocytosis +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Ewing Sarcoma +

Histiocytic And Dendritic Cell Neoplasm +

Mast Cell Leukemia +

Myelodysplastic Syndromes +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thymic Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.