Overview

Location [1]
1q43-q44
Pathway
PI3K/AKT1/MTOR
Protein [2]
RAC-gamma serine/threonine-protein kinase
Synonyms [1]
MPPH, MPPH2, STK-2, RAC-PK-gamma, RAC-gamma, PKB-GAMMA, PKBG, PRKBG

V-akt murine thymoma viral oncogene homolog 2 (AKT3) is a gene that encodes a protein serine/threonine kinase that plays a role in insulin and growth factor signaling. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

AKT3 is altered in 1.08% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

AKT3 GENIE Cases - Top Diseases

The most common alterations in AKT3 are AKT3 Mutation (0.95%), AKT3 Amplification (0.30%), AKT3 Loss (0.04%), AKT3 E17K (0.03%), and AKT3 K273K (0.01%) [3].

AKT3 GENIE Cases - Top Alterations

Significance of AKT3 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Melanoma +

Squamous Cell Lung Carcinoma +

Prostate Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Hepatocellular Carcinoma +

Renal Cell Carcinoma +

Small Cell Lung Carcinoma +

Endometrial Carcinoma +

Urothelial Carcinoma +

Cancer +

Pancreatic Carcinoma +

Malignant Glioma +

Ovarian Carcinoma +

Glioblastoma +

Aggressive Systemic Mastocytosis +

B-Cell Non-Hodgkin Lymphoma +

Cholangiocarcinoma +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Ewing Sarcoma +

Gastric Adenocarcinoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Liposarcoma +

Mast Cell Leukemia +

Multiple Myeloma +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Osteosarcoma +

Pecoma +

Peritoneal Mesothelioma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thymic Carcinoma +

Thyroid Gland Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.