Overview

Location [1]
1q43-q44
Pathway
PI3K/AKT1/MTOR
Synonyms [1]
PRKBG, MPPH2, STK-2, RAC-gamma, PKB-GAMMA, MPPH, PKBG, RAC-PK-gamma

V-akt murine thymoma viral oncogene homolog 2 (AKT3) is a gene that encodes a protein serine/threonine kinase that plays a role in insulin and growth factor signaling. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Significance of AKT3 in Diseases

Malignant Solid Tumor +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Colorectal Carcinoma +

Non-Hodgkin Lymphoma +

Head And Neck Squamous Cell Carcinoma +

Hepatocellular Carcinoma +

Melanoma +

Prostate Carcinoma +

Renal Cell Carcinoma +

Small Cell Lung Carcinoma +

Squamous Cell Lung Carcinoma +

Aggressive Systemic Mastocytosis +

B-Cell Non-Hodgkin Lymphoma +

Cancer +

Cholangiocarcinoma +

Chondrosarcoma +

Classical Hodgkin Lymphoma +

Desmoid-Type Fibromatosis +

Endometrial Carcinoma +

Ewing Sarcoma +

Gastric Adenocarcinoma +

Hematologic And Lymphocytic Disorder +

Hematopoietic And Lymphoid Malignancy +

Hematopoietic And Lymphoid System Neoplasm +

Histiocytic And Dendritic Cell Neoplasm +

Liposarcoma +

Malignant Glioma +

Mast Cell Leukemia +

Multiple Myeloma +

Myelodysplastic Syndromes +

Myeloid Neoplasm +

Osteosarcoma +

Ovarian Carcinoma +

Pecoma +

Pancreatic Carcinoma +

Peritoneal Mesothelioma +

Systemic Mastocytosis With An Associated Hematological Neoplasm (SM-AHN) +

Thymic Carcinoma +

Thyroid Gland Carcinoma +

Undifferentiated Pleomorphic Sarcoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.