Overview

Location [1]
3q27.3
Protein [2]
B-cell lymphoma 6 protein
Synonyms [1]
LAZ3, BCL5, ZNF51, ZBTB27, BCL6A

B-cell CLL/lymphoma 6 (BCL6) is a gene that encodes a protein that is a zinc finger transcription factor. The protein functions in transcriptional repression and the regulation of interleukin dependent responses in B-cells. Missense mutations, nonsense mutations, silent mutations, frameshift insertions and deletions, and in-frame deletions are observed in cancers such as esophageal cancer, intestinal cancer, and stomach cancer.

BCL6 is altered in 1.58% of all cancers with non-small cell lung carcinoma, colorectal adenocarcinoma, breast carcinoma, uterine corpus neoplasm, and malignant glioma having the greatest prevalence of alterations [3].

BCL6 GENIE Cases - Top Diseases

The most common alterations in BCL6 are BCL6 Amplification (0.36%), BCL6 Loss (0.04%), BCL6 R594Q (0.02%), BCL6 A172T (0.01%), and BCL6 K474Efs*26 (0.01%) [3].

BCL6 GENIE Cases - Top Alterations

Significance of BCL6 in Diseases

Diffuse Large B-Cell Lymphoma +

Double-Hit Lymphoma +

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

Triple-Hit Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Transformed Lymphoma +

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma +

B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma +

Follicular Lymphoma +

Grade 3b Follicular Lymphoma +

Non-Hodgkin Lymphoma +

Burkitt Lymphoma +

Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation +

Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type +

Primary Central Nervous System Lymphoma +

EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma +

High Grade B-Cell Lymphoma, Not Otherwise Specified +

Intravascular Large B-Cell Lymphoma +

Lymphomatoid Granulomatosis +

Mantle Cell Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Richter Syndrome +

Acute Myeloid Leukemia +

ALK-Positive Large B-Cell Lymphoma +

Burkitt Leukemia +

Chronic Lymphocytic Leukemia +

Extranodal Marginal Zone Lymphoma Of Mucosa-Associated Lymphoid Tissue +

Hematopoietic And Lymphoid Malignancy +

Hodgkin Lymphoma +

Lymphoplasmacytic Lymphoma +

Marginal Zone Lymphoma +

Mature T-Cell And NK-Cell Lymphoma/Leukemia +

Multiple Myeloma +

Nodal Marginal Zone Lymphoma +

Primary Effusion Lymphoma +

Splenic Marginal Zone Lymphoma +

Waldenstrom Macroglobulinemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.