Location [1]
Protein [2]
BCL-6 corepressor
Synonyms [1]

BCL6 corepressor (BCOR) is a gene that encodes the BCL-6 corepressor protein. BCOR is a member of the ankyrin repeat domain containing gene family. The corepressor expressed by BCOR binds to BCL6, a DNA-binding protein that acts as a transcription repressor for genes involved in regulation of B cells, a type of immune cell (Gene 2014a2014bGenetics Home Reference 2014). BCOR mutations have been observed in myelodysplastic syndromes, endometrial cancer, and other cancers.​

BCOR is altered in 3.75% of all cancers with lung adenocarcinoma, endometrial endometrioid adenocarcinoma, colon adenocarcinoma, acute myeloid leukemia, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

BCOR GENIE Cases - Top Diseases

The most common alterations in BCOR are BCOR Mutation (3.39%), BCOR Frameshift (0.63%), BCOR Nonsense (0.44%), BCOR N1459S (0.34%), and BCOR Loss (0.22%) [3].

BCOR GENIE Cases - Top Alterations

Significance of BCOR in Diseases

Myelodysplastic Syndromes +

Acute Myeloid Leukemia +

Secondary Acute Myeloid Leukemia +

Acute Lymphoblastic Leukemia +

Therapy-Related Acute Myeloid Leukemia +

Chronic Myelomonocytic Leukemia +

Myelodysplastic/Myeloproliferative Neoplasm +

Therapy-Related Myelodysplastic Syndrome +

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome +

Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.