Overview

Location [1]
11q13.5
Pathways
DNA damage/repair, Cell cycle control
Synonyms [1]
GL002, EMSY

C11orf30 is altered in 0.53% of all cancers with lung adenocarcinoma, cutaneous melanoma, high grade ovarian serous adenocarcinoma, bladder urothelial carcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

C11orf30 GENIE Cases - Top Diseases

The most common alterations in C11orf30 are C11orf30 Mutation (2.22%), C11orf30 R744S (0.13%), C11orf30 T150M (0.16%), C11orf30 I494V (0.16%), and C11orf30 P439S (0.28%) [3].

C11orf30 GENIE Cases - Top Alterations

Significance of C11orf30 in Diseases

Malignant Solid Tumor +

Prostate Adenocarcinoma +

Prostate Carcinoma +

Breast Carcinoma +

Ovarian Carcinoma +

Cervical Carcinoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Primary Peritoneal Carcinoma +

Non-Small Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Head And Neck Squamous Cell Carcinoma +

Endometrial Carcinoma +

Cholangiocarcinoma +

Fallopian Tube Carcinoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Malignant Small Intestinal Neoplasm +

Small Cell Lung Carcinoma +

Bladder Urothelial Carcinoma +

Urothelial Carcinoma +

Melanoma +

Esophageal Carcinoma +

Clear Cell Renal Cell Carcinoma +

Gastric Carcinoma +

Malignant Gastric Neoplasm +

Malignant Esophagogastric Neoplasm +

Malignant Ovarian Epithelial Tumor +

High Grade Ovarian Serous Adenocarcinoma +

Cancer +

Malignant Intestinal Neoplasm +

Soft Tissue Sarcoma +

Biliary Tract Carcinoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Ampulla Of Vater Carcinoma +

Anal Carcinoma +

Diffuse Large B-Cell Lymphoma +

Gastrointestinal Stromal Tumor +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Mesothelioma +

Penile Carcinoma +

Uveal Melanoma +

Vaginal Carcinoma +

Vulvar Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.