Overview

Location [1]
11q13.3
Pathway
Cell cycle control
Protein [2]
G1/S-specific cyclin-D1
Synonyms [1]
BCL1, U21B31, D11S287E, PRAD1

Cyclin D1 (CCND1) is a gene that encodes a protein that functions in the regulation of CDK kinases in the cell cycle. Fusions, rearrangements, missense mutations, nonsense mutations, silent mutations, and in-frame deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

CCND1 is altered in 4.40% of all cancers with breast carcinoma, non-small cell lung carcinoma, bladder carcinoma, uterine corpus neoplasm, and head and neck squamous cell carcinoma having the greatest prevalence of alterations [3].

CCND1 GENIE Cases - Top Diseases

The most common alterations in CCND1 are CCND1 Amplification (3.83%), CCND1 Mutation (0.63%), CCND1 P287S (0.03%), CCND1 Loss (0.03%), and CCND1 T286I (0.03%) [3].

CCND1 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of CCND1 in Diseases

Mantle Cell Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Malignant Solid Tumor +

Multiple Myeloma +

Follicular Lymphoma +

Diffuse Large B-Cell Lymphoma +

Breast Carcinoma +

Small Lymphocytic Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Non-Hodgkin Lymphoma +

Chronic Lymphocytic Leukemia +

Lymphoplasmacytic Lymphoma +

Marginal Zone Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Acral Lentiginous Melanoma +

Anaplastic Large Cell Lymphoma +

Esophageal Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Bladder Carcinoma +

Urothelial Carcinoma +

Squamous Cell Lung Carcinoma +

Hepatocellular Carcinoma +

Melanoma +

Gastric Carcinoma +

Non-Small Cell Lung Carcinoma +

Lymphoma +

Colorectal Carcinoma +

Malignant Glioma +

Cancer +

Germ Cell Tumor +

Grade 3b Follicular Lymphoma +

Histiocytic And Dendritic Cell Neoplasm +

Plasma Cell Leukemia +

Waldenstrom Macroglobulinemia +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.