Location [1]
Cell cycle control
Protein [2]
G1/S-specific cyclin-D1
Synonyms [1]
PRAD1, D11S287E, BCL1, U21B31

Cyclin D1 (CCND1) is a gene that encodes a protein that functions in the regulation of CDK kinases in the cell cycle. Fusions, rearrangements, missense mutations, nonsense mutations, silent mutations, and in-frame deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

CCND1 is altered in 4.10% of all cancers with breast invasive ductal carcinoma, invasive breast carcinoma, bladder urothelial carcinoma, breast invasive lobular carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

CCND1 GENIE Cases - Top Diseases

The most common alterations in CCND1 are CCND1 Amplification (3.83%), CCND1 Mutation (0.62%), CCND1 Loss (0.04%), CCND1 P287S (0.05%), and CCND1 Fusion (0.05%) [3].

CCND1 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of CCND1 in Diseases

Mantle Cell Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Malignant Solid Tumor +

Multiple Myeloma +

Follicular Lymphoma +

Diffuse Large B-Cell Lymphoma +

Marginal Zone Lymphoma +

Breast Carcinoma +

Chronic Lymphocytic Leukemia +

Bladder Carcinoma +

Melanoma +

B-Cell Non-Hodgkin Lymphoma +

Non-Hodgkin Lymphoma +

Colorectal Carcinoma +

Small Lymphocytic Lymphoma +

Transformed Non-Hodgkin Lymphoma +

Urothelial Carcinoma +

Non-Small Cell Lung Carcinoma +

Malignant Glioma +

Soft Tissue Sarcoma +

Grade 3b Follicular Lymphoma +

Lymphoplasmacytic Lymphoma +

Waldenstrom Macroglobulinemia +

Esophageal Squamous Cell Carcinoma +

Hypopharyngeal Squamous Cell Carcinoma +

Laryngeal Squamous Cell Carcinoma +

Acral Lentiginous Melanoma +

Oral Cavity Carcinoma +

Oral Cavity Squamous Cell Carcinoma +

Esophageal Carcinoma +

Mucosal Melanoma +

Head And Neck Squamous Cell Carcinoma +

Squamous Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Head And Neck Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Malignant Uterine Neoplasm +

Gallbladder Carcinoma +

Cancer +

Bile Duct Carcinoma +

Anaplastic Large Cell Lymphoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Osteosarcoma +

Prostate Carcinoma +

Lung Carcinoma +

Liposarcoma +

Lung Adenocarcinoma +

Cervical Carcinoma +

Pancreatic Carcinoma +

Ovarian Carcinoma +

Meningioma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Germ Cell Tumor +

Bronchogenic Carcinoma +

Burkitt Lymphoma +

Chondrosarcoma +

Dedifferentiated Chondrosarcoma +

EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

High Grade B-Cell Lymphoma With MYC And BCL2 And/Or BCL6 Rearrangements +

Histiocytic And Dendritic Cell Neoplasm +

Hodgkin Lymphoma +

Lymphoblastic Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Plasma Cell Leukemia +

Primary Central Nervous System Lymphoma +

Primary Mediastinal B-Cell Lymphoma +

Richter Syndrome +

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.