Overview

Location [1]
11q13.3
Pathway
Cell cycle control
Synonyms [1]
D11S287E, PRAD1, U21B31, BCL1

Cyclin D1 (CCND1) is a gene that encodes a protein that functions in the regulation of CDK kinases in the cell cycle. Fusions, rearrangements, missense mutations, nonsense mutations, silent mutations, and in-frame deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

Biomarker-Directed Therapies

Significance of CCND1 in Diseases

Mantle Cell Lymphoma +

Mature B-Cell Lymphoma/Leukemia +

Malignant Solid Tumor +

Multiple Myeloma +

Follicular Lymphoma +

Diffuse Large B-Cell Lymphoma +

Marginal Zone Lymphoma +

Breast Carcinoma +

Chronic Lymphocytic Leukemia +

B-Cell Non-Hodgkin Lymphoma +

Bladder Carcinoma +

Colorectal Carcinoma +

Melanoma +

Non-Hodgkin Lymphoma +

Small Lymphocytic Lymphoma +

Transformed Non-Hodgkin Lymphoma +

Grade 3b Follicular Lymphoma +

Lymphoplasmacytic Lymphoma +

Malignant Glioma +

Non-Small Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Urothelial Carcinoma +

Waldenstrom Macroglobulinemia +

Acral Lentiginous Melanoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Anaplastic Large Cell Lymphoma +

Bile Duct Carcinoma +

Bronchogenic Carcinoma +

Burkitt Lymphoma +

Cancer +

Cervical Carcinoma +

Chondrosarcoma +

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma +

Dedifferentiated Chondrosarcoma +

EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

Esophageal Carcinoma +

Esophageal Squamous Cell Carcinoma +

Gallbladder Carcinoma +

Gastric Adenocarcinoma +

Gastric Carcinoma +

Germ Cell Tumor +

Grade 1 Follicular Lymphoma +

Grade 2 Follicular Lymphoma +

Grade 3 Follicular Lymphoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

High Grade B-Cell Lymphoma With MYC And BCL2 And/Or BCL6 Rearrangements +

Histiocytic And Dendritic Cell Neoplasm +

Hodgkin Lymphoma +

Hypopharyngeal Squamous Cell Carcinoma +

Laryngeal Squamous Cell Carcinoma +

Liposarcoma +

Lung Adenocarcinoma +

Lung Carcinoma +

Lymphoblastic Lymphoma +

Malignant Uterine Neoplasm +

Mediastinal Large B-Cell Lymphoma +

Meningioma +

Mucosal Melanoma +

Oral Cavity Carcinoma +

Oral Cavity Squamous Cell Carcinoma +

Oropharyngeal Squamous Cell Carcinoma +

Osteosarcoma +

Ovarian Carcinoma +

Pancreatic Carcinoma +

Plasma Cell Leukemia +

Primary Central Nervous System Lymphoma +

Primary Mediastinal B-Cell Lymphoma +

Prostate Carcinoma +

Richter Syndrome +

Squamous Cell Lung Carcinoma +

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.