Overview

Location [1]
12p13.32
Pathway
Cell cycle control
Protein [2]
G1/S-specific cyclin-D2
Synonyms [1]
KIAK0002, MPPH3

Cyclin D2 (CCND2) is a gene that encodes for a protein that functions in the regulation of CDK kinases in the cell cycle. Fusions, missense, nonsense, and silent mutations are observed in cancers such as esophageal cancer, skin cancer, and stomach cancer.

CCND2 is altered in 1.24% of all cancers with colon adenocarcinoma, lung adenocarcinoma, testicular mixed germ cell tumor, breast invasive ductal carcinoma, and conventional glioblastoma multiforme having the greatest prevalence of alterations [3].

CCND2 GENIE Cases - Top Diseases

The most common alterations in CCND2 are CCND2 Amplification (0.85%), CCND2 Mutation (0.54%), CCND2 Loss (0.07%), CCND2 R262C (0.01%), and CCND2 R285Q (0.01%) [3].

CCND2 GENIE Cases - Top Alterations

Significance of CCND2 in Diseases

Malignant Solid Tumor +

Malignant Glioma +

Non-Hodgkin Lymphoma +

Germ Cell Tumor +

Colorectal Carcinoma +

Squamous Cell Lung Carcinoma +

Soft Tissue Sarcoma +

Breast Carcinoma +

Chondrosarcoma +

Dedifferentiated Chondrosarcoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Meningioma +

Osteosarcoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.