Overview

Location [1]
12p13.32
Pathway
Cell cycle control
Synonyms [1]
KIAK0002, MPPH3

Cyclin D2 (CCND2) is a gene that encodes for a protein that functions in the regulation of CDK kinases in the cell cycle. Fusions, missense, nonsense, and silent mutations are observed in cancers such as esophageal cancer, skin cancer, and stomach cancer.

Significance of CCND2 in Diseases

Malignant Solid Tumor +

Malignant Glioma +

Non-Hodgkin Lymphoma +

Breast Carcinoma +

Chondrosarcoma +

Colorectal Carcinoma +

Dedifferentiated Chondrosarcoma +

Esophageal Carcinoma +

Gastric Carcinoma +

Germ Cell Tumor +

Histiocytic And Dendritic Cell Neoplasm +

Mantle Cell Lymphoma +

Meningioma +

Osteosarcoma +

Soft Tissue Sarcoma +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.